Antabuse (disulfiram) blocks an enzyme that is involved in metabolizing alcohol intake. Disulfiram produces very unpleasant side effects when combined with alcohol in the body. Antabuse is used in certain people with chronic alcoholism. This medicine can help keep you from drinking because of the unpleasant side effects that will occur if you consume alcohol while taking Antabuse. Antabuse is used together with behavior modification, psychotherapy, and counseling support to help you stop drinking. You should not use Antabuse if you have recently taken metronidazole or paraldehyde, or if you have consumed any foods or products that contain alcohol (mouthwash, cough medicine, cooking wine or vinegar, certain desserts, and others). Antabuse should never be given to a person without his or her knowledge of taking the medicine. Do not take Antabuse if you have consumed alcohol within the past 12 hours. 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Antabuse® is the trade name for an organic sulfur com-pound, chemically identical to disulfiram or tetraethyl-thiuram disulfide. subsequent history. Disulfiram tetraethylthiuramdisulfide was accidentally discovered to combine with ethyl alcohol to produce a noxious effect by Jacobsen and Hald, in Denmark, Jun 16, 2018. Antabuse, or disulfiram as it is also known, was the first medicine approved for the treatment of alcohol abuse and alcohol dependence.