Ciprofloxacin synthesis

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  1. dreel Well-Known Member

    Ciprofloxacin synthesis


    Ciprofloxacin is a fluoroquinolone (flor-o-KWIN-o-lone) antibiotic that fights bacteria in the body. It is used to treat different types of bacterial infections, including skin infections, bone and joint infections, respiratory or sinus infections, urinary tract infections, and certain types of diarrhea. Ciprofloxacin is also used to treat people who have been exposed to anthrax or certain types of plague. Ciprofloxacin should be used only for infections that cannot be treated with a safer antibiotic. Fluoroquinolone antibiotics can cause serious or disabling side effects that may not be reversible, such as tendon rupture or nerve problems. Ciprofloxacin can cause serious side effects, including tendon problems, nerve damage, serious mood or behavior changes, or low blood sugar. Stop using this medicine and call your doctor at once if you have symptoms such as: headache, hunger, irritability, numbness, tingling, burning pain, confusion, agitation, paranoia, problems with memory or concentration, thoughts of suicide, or sudden pain or movement problems in any of your joints. In rare cases, ciprofloxacin may cause damage to your aorta, which could lead to dangerous bleeding or death. This includes bone and joint infections, intra abdominal infections, certain type of infectious diarrhea, respiratory tract infections, skin infections, typhoid fever, and urinary tract infections, among others. Ciprofloxacin is used to treat a wide variety of infections, including infections of bones and joints, endocarditis, gastroenteritis, malignant otitis externa, respiratory tract infections, cellulitis, urinary tract infections, prostatitis, anthrax, and chancroid. Ciprofloxacin only treats bacterial infections; it does not treat viral infections such as the common cold. For certain uses including acute sinusitis, lower respiratory tract infections and uncomplicated gonorrhea, ciprofloxacin is not considered a first-line agent. Ciprofloxacin occupies an important role in treatment guidelines issued by major medical societies for the treatment of serious infections, especially those likely to be caused by Gram-negative bacteria, including Pseudomonas aeruginosa. For example, ciprofloxacin in combination with metronidazole is one of several first-line antibiotic regimens recommended by the Infectious Diseases Society of America for the treatment of community-acquired abdominal infections in adults. In other cases, treatment guidelines are more restrictive, recommending in most cases that older, narrower-spectrum drugs be used as first-line therapy for less severe infections to minimize fluoroquinolone-resistance development.

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    Ciprofloxacin C17H18FN3O3 CID 2764 - structure, chemical names, physical and chemical. Anti-Infective Agents; Nucleic Acid Synthesis Inhibitors. National. Scheme 6. Synthesis of 7-4-5-amino-1,3,4 thiadiazole-2-sulfonyl ciprofloxacin 19. Scheme 7. Synthesis of ciprofloxacin derivatives 22 using fluoroquinolone carboxylic acids 20. Scheme 8. Synthesis of symmetric ciprofloxacin dimmers 24. 1854 R. AKHTAR ET AL. Evolution of different syntheses of ciprofloxacin are described. A high yielding two step synthesis from 2,4-dichloro-5-fluoro benzoylchloride is described.

    The condensation of 2,4-dichloro-5-fluorobenzoyl chloride (I) with diethyl malonate by means of magnesium ethoxide in ether gives diethyl 2,4-dichloro-5-fluorobenzoylmalonate (II), which is partially hydrolyzed and decarboxylated with p-toluenesulfonic acid water yielding ethyl 2,4-dichloro-5-fluorobenzoylacetate . Condensation of this with triethyl orthoformate in refluxing acetic anhydride affords ethyl 2-(2,4-dichloro-5-fluorobenzoyl)-3-ethoxyacrylate (III), which is treated with cyclopropylamine (IV) in ethanol to give ethyl 2-(2,4-dichloro-5-fluorobenzoyl)-3-cyclopropylaminoacrylate . The cyclization of ethyl 2-(2,4-dichloro-5-fluorobenzoyl)-3-cyclopropylaminoacrylate with Na H in refluxing dioxane yields 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (V), which is finally condensed with piperazine in hot DMSO to afford the target compound ciprofloxacin. Ciprofloxacin (CP), an antibiotic has been shown to have antiproliferative and apoptotic activities in several cancer cell lines. Moreover, several reports have highlighted the interest of increasing the lipophilicity to improve the antitumor efficacy. These studies have led us to synthesize new CP derivatives of various lipophilicities and to evaluate their activity in five human cancer cell lines. With an easy and cost-efficient procedure, 31 7-((4-substituted)piperazin-1-yl) derivatives of CP were prepared that displayed IC80 mg/kg. Several derivatives displayed higher in vitro antitumor activity than parent CP however this was not dependent on the lipophilicity of the substituent.

    Ciprofloxacin synthesis

    Synthesis of ciprofloxacin hydrochloride - Ciprofloxacin., Synthesis of ciprofloxacin-based compounds A review

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  5. Ciprofloxacin is an antibiotic used to treat a number of bacterial infections. This includes bone and joint infections, intra abdominal infections, certain type of.

    • Ciprofloxacin - Wikipedia.
    • Ciprofloxacin A Two Step Process - Der Pharma Chemica.
    • Ciprofloxacin Cipro Uses, Dosage, Side Effects -.

    Mal method can be utilized to obtain the ciprofloxacin complexes with Cu2+, Mn2+ and Zr2+ as the metal. synthesize all kinds of complexes, with ciprofloxacin. Jan 16, 2009. Synthesis and antimicrobial activity of ciprofloxacin and norfloxacin permanently bonded to polyethylene glycol by a thiourea linker. Three figures Fig. S1, S2, S3 for the lowest energy models of the Mncf 2 H 2 O 2, Fecf 3 and MoO 2 cf 2 enantiomers, respectively. Mononuclear metal complexes with ciprofloxacin Synthesis, characterization and DNA-binding properties.

     
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    Comparison of 4 and 10 days of doxycycline treatment for urinary. J Urol. 1980 Nov;1245643-5. Comparison of 4 and 10 days of doxycycline treatment for urinary tract infection. Lockey JE, Williams DN, Raij L, Sabath LD.

    How much & for how long should I take Doxycycline Hyclate for.