Tamoxifen and diabetes

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  1. RSAlien XenForo Moderator

    Tamoxifen and diabetes


    Tamoxifen may cause cancer of the uterus (womb), strokes, and blood clots in the lungs. Tell your doctor if you have ever had a blood clot in the lungs or legs, a stroke, or a heart attack. Also tell your doctor if you smoke, if you have high blood pressure or diabetes, if your ability to move around during your waking hours is limited, or if you are taking anticoagulants ('blood thinners') such as warfarin (Coumadin). If you experience any of the following symptoms during or after your treatment, call your doctor immediately: abnormal vaginal bleeding; irregular menstrual periods; changes in vaginal discharge, especially if the discharge becomes bloody, brown, or rusty; pain or pressure in the pelvis (the stomach area below the belly button); leg swelling or tenderness; chest pain; shortness of breath; coughing up blood; sudden weakness, tingling, or numbness in your face, arm, or leg, especially on one side of your body; sudden confusion; difficulty speaking or understanding; sudden difficulty seeing in one or both eyes; sudden difficulty walking; dizziness; loss of balance or coordination; or sudden severe headache. You will need to have gynecological examinations (examinations of the female organs) regularly to find early signs of cancer of the uterus. If you are thinking about taking tamoxifen to reduce the chance that you will develop breast cancer, you should talk to your doctor about the risks and benefits of this treatment. You and your doctor will decide whether the possible benefit of tamoxifen treatment is worth the risks of taking the medication. If you need to take tamoxifen to treat breast cancer, the benefits of tamoxifen outweigh the risks. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with tamoxifen and each time you refill your prescription. Tamoxifen is an estrogen receptor blocking agent preventing the stimulatory action of estrogen on the cancer cells. Since more than 70% of all breast cancers are estrogen receptor positive, Tamoxifen is most commonly used treatment in these cases. Tamoxifen is an important drug in the treatment of breast cancer. It is an estrogen receptor blocking agent which prevents the stimulatory action of estrogen on the cancer cells. More than 70% of all breast cancers are estrogen receptor positive and tamoxifen is the mainstay of treatment in these cases. It is also used as a cancer preventing medicine in women with more than normal levels of estrogen, who are at an increased risk of developing the disease. However, a new study has found that tamoxifen may increase the risk of diabetes in women predisposed to it.

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    Tamoxifen Nolvadex prescribed for the prevention and treatment of breast cancer in men and women, and occasionally, to stimulate ovulation in women. Common side effects include depression, nausea, vomiting, and headache. WARNING Uterine cancer, stroke, and blood clots in the lung have been reported when using tamoxifen for risk-reduction of breast cancer. Oct 28, 2014 · The possibility that diabetes predisposes to breast cancer or that a common underlying factor may predispose to both diabetes and breast cancer is an issue which needs to be considered; however, it is less likely because Figure 2 illustrates increased diabetes risk for tamoxifen users among women diagnosed with breast cancer over time. Tamoxifen is one of the most widely prescribed drugs to prevent a recurrence. may contribute to an increased risk of developing type 2 diabetes.

    , Canadian researchers found an increased rate of diabetes among breast cancer survivors who were given tamoxifen. Researchers looked at medical data on more than 14,000 women ages 65 and up who had undergone breast cancer treatment. They found that 10% of those women were diagnosed with diabetes and that women treated with tamoxifen were at a 24% higher risk of being diagnosed. While the study did not indicate a causal link between side effects of Tamoxifen and diabetes, the researchers said their findings suggest the medication may increase the susceptibility of women who were already likely to develop diabetes. Tamoxifen was first approved by the FDA in 1971 for the treatment of breast cancer. Originally developed by Astra Zeneca under the brand name Nolvadex, it is now sold under a variety of brand names, including Istubal and Valodex, and is also sold as a generic. Tamoxifen works by inhibiting the development of estrogen, which is believed to stimulate the spread of breast cancer. Mimi791 wrote: I was diagnosed yesterday with type 2 diabetes and my doc says it's probably because of the Tamoxifen. I have a blood profile done at my annual visit with my ob-gyn which is coming up again in a few months. Diane Jul 13, 2013 AM chef127 wrote: I think if you are predisposed to diabetes the tamox or AI's will excelerate it. Apparently estrogen regulates your insulin levels..if you don't have any..can get diabetes. I've seen comment threads in the Aromatase group but not Tamoxifen....cancer, the gift that keeps on giving... I've had genetic type 2 for over 20 years and I think that was one of the facters that led to a BC Dx.?? My sugar was ok the first 2 years on it, but started to go wonky last fall. Surgery 7/8/2009 Lymph node removal: Right, Underarm/Axillary; Mastectomy: Right; Prophylactic mastectomy: Left; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Jul 13, 2013 AM edwards750 wrote: Dang mimi that is a bummer. I was switched from Arimidex a year ago because I have osteoporsis and Arimidex attacks the bones. I have a friend who has it and found out by the dr running a test for something else. I try to control it with meds, diet and exercise but life gets in my way. I realize it is too late to prevent diabetes but we both know there are a number of SEffects with this drug. So is your dr thinking you should get off the Tamoxifen... That is one of the reasons I don't take any antihormonals. I take DIM and a Rx'ed herbal TEA to get rid of the "bad"estrogenes. We know the drugs DO work to take away our hormones and hopefully stop progression.

    Tamoxifen and diabetes

    Tamoxifen shown to protect against obesity and. - Diabetes UK, Association of tamoxifen use and increased diabetes among.

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  6. The findings do not mean tamoxifen is a direct cause of diabetes in this patient population, the study authors emphasized, but they said its use.

    • Small Increase in Diabetes Risk Seen in Older Breast Cancer..
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    • Tamoxifen MedlinePlus Drug Information.

    Tamoxifen therapy was found to be associated with increased incidence of diabetes in postmenopausal breast cancer patients. Benefits of Tamoxifen Therapy Outweigh Its Side Effects The researchers selected more than 14,000 women above the age of 65 who had been diagnosed with early breast cancer between the years 19. Tamoxifen may increase diabetes incidence through its estrogen-inhibiting effects. This study assessed whether tamoxifen treatment in older. Abstract. Type 1 diabetes T1D results from the destruction of pancreatic β-cell through the β-cell specific autoimmune process. β-cell autoantigens.

     
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