Her oncologist recently took her off Tamoxifen after her 5 year anniversary. And approximately two months after she was completely off the medication, she had what she thinks was a mild monthly period. She is 66 years old, and this naturally alarmed her. She immediately went to her oncologist who prescribed a series of tests. All of her blood work, ultrasounds, MRI's, etc turned out fine. However, he seems to think that this was not a menstrual cycle and wants her to visit an OB/GYN. She has made an appointment but has asked me to try to locate some information on withdrawal symptoms of Tamoxifen on the Internet. My mother also runs a breast cancer support group at the local cancer center and feels that this information would be helpful to the other women in the group. Could you possibly point me in the right direction to find this information? Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial [published online ahead of print December 5, 2012]. Tamoxifen is widely used to treat estrogen-receptor–positive (ER-positive) breast cancer and is generally prescribed for 5 years of daily use once the cancer has been excised. Adjuvant Tamoxifen: Longer Against Shorter (ATLAS) Collaborative Group. Women who have hormone-sensitive breast cancer and who have taken tamoxifen for 5 years as adjuvant therapy stand to benefit from an additional 5 years of the drug, according to preliminary findings from the Adjuvant Tamoxifen: Longer Against Shorter (ATLAS) trial. The drug substantially reduces the breast cancer mortality rate not only while treatment continues, but throughout the first 15 years after diagnosis. Mindy Goldman, MD “The results of this trial have been long-awaited and are very exciting,” said Mindy Goldman, MD, director of the Women’s Cancer Care Program in the Department of Obstetrics, Gynecology, and Reproductive Sciences at the University of California, San Francisco. “I think these results will be translated into changes in clinical care right away.” Because breast cancer is very common, gynecologists need to be aware of the gynecologic effects of drugs like tamoxifen, Dr. Gynecologists “need to ask their patients how long they have been on tamoxifen and about side effects they may be having.” Although menopausal symptoms such as hot flashes improve over time in women who take tamoxifen, some women may continue to experience bothersome symptoms longer with the extended therapy, Dr. Among her recommendations: It was known that 5 years of tamoxifen are more effective than 2 years. Until now, however, it was unclear whether continuation beyond 5 years further reduces the 15-year breast cancer mortality rate. In the trial of 12,894 women, investigators randomly assigned those who had received tamoxifen for 5 years to another 5 years of therapy or to no additional therapy, regardless of ER status. Buy cialis daily use Alternative to sertraline Sildenafil solubility Dec 6, 2012. Between years 5 to 14 after initial diagnosis, breast cancer mortality was 15% for those women who stopped Tamoxifen at 5 years and 12.2%. However, women who took tamoxifen for 5 years had a 0.6% chance per year of having their breast cancer return in the same breast this is. Jan 10, 2006. My mother is a 5 year breast cancer survivor. Her oncologist recently took her off Tamoxifen after her 5 year anniversary. She gradually weaned. Recent large trials have shown the survival benefits of 10-year use of tamoxifen by reducing late recurrence compared with 5-year therapy in estrogen receptor(ER)-positive breast cancer. We tried to identify clinical factors associated with the late recurrence. We reviewed our database of ER-positive patients who had received operations between 19 in two institutions. We selected 444 who had completed 5-year tamoxifen and were disease-free up to 10 years after the operation. Patients who had received aromatase inhibitors with any regimens were excluded. As a late recurrence group, 139 patients were identified who had completed 5-year tamoxifen, but had recurrence afterwards. Among them, 61 had local/contralateral breast recurrence and 78 had distant metastasis. Clinicopathological factors at the time of initial operation, such as age, menopausal status, progesterone receptor expression, HER2 status, tumor grade and Ki-67, were compared between the disease-free group and the late recurrence group. Margaret Andrews couldn’t wait to be done with hormonal therapy: treatment for hormone receptor-positive breast cancer, which grows because of the hormones estrogen or progesterone. After a stage IIb breast cancer diagnosis in 1999, Margaret had surgery, chemotherapy and radiation therapy. She then began taking tamoxifen before switching to an aromatase inhibitor (AI). I was tired of muscle aches and sexual side effects,” says Margaret, 70, a retired teacher who lives in Hollis, Alaska. She thought she would be on the AI anastrozole (Arimidex) for 5 years, which quickly began to feel like a very long time. At her checkup in 2007, Margaret received some unexpected news: The oncologist recommended she take anastrozole for another 5 years. That was an unusual suggestion then, but early research was beginning to suggest women with hormone receptor-positive breast cancer might receive more protection from a new breast cancer or cancer coming back if they took hormonal therapy beyond the usual 5 years. Margaret says she and her husband “were so disappointed because we were looking forward to the time when I could be off it.” But she decided to continue hormonal therapy. Many women with hormone receptor-positive, early-stage breast cancer face the same choice Margaret did. Tamoxifen 5 years Years of Tamoxifen Better Than 5 Study - MedicineNet, Hormonal Therapy for Pre-menopausal Women with Early Stage. Kamagra india pharmacyViagra femininoWhere can you buy viagra in storesLasix water pills side effectsLevitra for bph Jan 25, 2015. The benefits of tamoxifen as primary prevention of breast cancer are well. At a median follow-up of 16 years, women treated with 5 years of. Tamoxifen Prevention of Breast Cancer Extends More Than 16 Years. Tamoxifen Withdrawal OncoLink. Five Years of Tamoxifen Continues to Benefit Women 15 Years after.. Sep 20, 2016. She then began taking tamoxifen before switching to an aromatase inhibitor. Women in both groups were likely to be cancer free at 5 years of. Hello I have not been on this site for a long time- it really helped on my cancer journey- the club no one wants to belong to. I have recently. Dec 6, 2012. Ten years of tamoxifen ups cancer survival rates. of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of.