Duloxetina

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    Duloxetina


    La duloxetina es un antidepresivo en un grupo de medicamentos llamados inhibidores selectivos de la recaptación de serotonina y noradrenalina (IRSN), afecta a los químicos en su cerebro que pueden salir de balance y causar depresión. La duloxetina se usa para tratar el trastorno depresivo mayor y el trastorno de ansiedad general, también se usa para tratar la fibromialgia (un trastorno de dolor crónico), dolor muscular o dolor en las articulaciones (como dolor de espalda y dolor de la osteoartritis). En algunos casos la duloxetina se utiliza para tratar el dolor causado por daño a los nervios en las personas con diabetes. | Contraindicaciones | Administración | Dosis | Efectos Secundarios | Interacciones | Para Comprar Duloxetina (Cymbalta) haz clic aquí No usar duloxetina junto con thioridazine o un inhibidor de la MAO como furazolidona, isocarboxazida, fenelzina, rasagiline, selegilina o tranilcipromina, una interacción de drogas muy peligrosa puede ocurrir, resultando en efectos secundarios graves. Debe esperar por lo menos 14 días después de dejar de tomar un IMAO antes de que pueda tomar duloxetina. Después de dejar de tomar la duloxetina, debe esperar al menos 5 días antes de empezar a tomar un IMAO. Para asegurarse que usted puede tomar con seguridad duloxetina, dígale a su médico si usted tiene cualquiera de estas otras condiciones: enfermedad del hígado o del riñón; convulsiones o epilepsia; un trastorno de sangrado o coágulos sanguíneos; glaucoma; trastorno bipolar (maniaco depresivo), o una historia de abuso de drogas o pensamientos suicidas. Mostra-se eficaz não só no tratamento da depressão como também em outros distúrbios (incontinência urinária). É uma substância classificada como inibidor selectivo de recaptação de serotonina e noradrenalina. Atua ao nível do sistema nervoso central, melhorando sintomas depressivos e ansiosos a doses de 20mg e diminuindo a dor por compressão dos nervos (dor neuropática) em pacientes com Transtorno depressivo maior, fibromialgia e neuropatia diabética (dose de 60mg). , Dulorgran (Germed Pharma), Xeristar, Yentreve, Ariclaim, Velija (Libbs), Cymbi (EMS Sigma Pharma), Dual (ACHÉ), Abretia (FQM). A duloxetina é um novo antidepressivo, criado pelo laboratório estadunidense Eli Lilly. Pertence a uma classe de drogas conhecidas como inibidores seletivos de recaptação de serotonina e noradrenalina (ISRSN). Os neurotransmissores são liberados por um neurônio e são captados por outro. Uma pequena quantidade de neurotransmissor é enviada de cada vez, de um neurônio para outro.

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    Medscape - Generalized anxiety disorder, major depressive disorder, fibromyalgia-specific dosing for Cymbalta duloxetine, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor SNRI. This medication works by helping to restore the balance of certain natural substances serotonin and norepinephrine in the brain. DESCRIPTION. CYMBALTA ® duloxetine delayed-release capsules is a selective serotonin and norepinephrine reuptake inhibitor SSNRI for oral administration. Its chemical designation is +-S-N-methyl-γ-1-naphthyloxy-2-thiophenepropylamine hydrochloride.

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We may share your information with third-party partners for marketing purposes. To learn more and make choices about data use, visit our Advertising Policy and Privacy Policy. 40-60 mg/day PO initially (in single daily dose or divided q12hr for 1 week if patient needs to adjust to therapy) Titrate dose in increments of 30 mg/day over 1 week as tolerated Target dosage: 60 mg/day PO (in single daily dose or divided q12hr); not to exceed 120 mg/day (safety of dosages Treatment of chronic musculoskeletal pain, including discomfort from osteoarthritis and chronic lower back pain 30 mg/day PO initially for 1 week to allow for therapy adjustment Target dosage: 60 mg/day PO; not to exceed 60 mg/day Dosages ≥60 mg/day have not been shown to offer additional benefits Major depressive disorder and generalized anxiety disorder: Acute episodes often necessitate several months of sustained therapy Diabetic peripheral neuropathic pain: Efficacy for 12 weeks has not been studied; if diabetes is complicated by renal disease, consider lower starting dosage with gradual increase to effective dosage Fibromyalgia: Efficacy for ≥12 weeks has not been studied; continue treatment on basis of individual patient response Chronic musculoskeletal pain: Efficacy for ≥13 weeks has not been studied Uncontrolled narrow-angle glaucoma: Use not recommended due to increased risk of mydriasis Constipation (10%) Dizziness (10%) Insomnia (10%) Diarrhea (9-10%) Anorexia (8%) Decreased appetite (7-8%) Abdominal pain (6%) Hyperhidrosis (6%) Increased sweating (6%) Agitation (5%) Nasopharyngitis (5%) Vomiting (3-5%) Male sexual dysfunction (2-5%) Abdominal pain (4%) Decreased libido (4%) Musculoskeletal pain (4%) Upper respiratory tract infection (URTI) (4%) Abnormal orgasm (3%) Agitation (3%) Anxiety (3%) Blurred vision (3%) Cough (3%) Influenza (3%) Muscle spasms (3%) Tremor (3%) Abnormal dreams (2%) Dyspepsia (2%) Hot flushes (2%) Nausea (2%) Oropharyngeal pain (2%) Palpitations (2%) Paresthesia (2%) Weight loss (2%) Yawning (2%) Dysuria ( General: Anaphylactic reaction, angioneurotic edema, hypersensitivity Cardiovascular: Hypertensive crisis, supraventricular arrhythmia, myocardial infarction, tachycardia, Takotsubo cardiomyopathy Endocrine: Galactorrhea, gynecologic bleeding, hyperglycemia, hyperprolactinemia Neurologic: Restless legs syndrome, seizures upon treatment discontinuance, extrapyramidal disorders Ophthalmic: Glaucoma Otic: Tinnitus (upon treatment discontinuance) Psychiatric: Aggression and anger (particularly early in treatment or after treatment discontinuance), hallucinations Musculoskeletal: Trismus, muscle spasm Skin: Serious skin reactions (eg, erythema multiforme and Stevens-Johnson syndrome) necessitating drug discontinuance or hospitalization, urticaria, rash Gastrointestinal: Colitis (microscopic or unspecified),cutaneous vasculitis (sometimes associated with systemic involvement), acute pancreatitis Antidepressants increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term studies These studies did not show an increase in the risk of suicidal thoughts and behavior with antidepressant use in patients 24 yr There was a reduction in risk with antidepressant use in patients ≥65 yr In patients of all ages who are started on antidepressant therapy, monitor closely for worsening, and for emergence of suicidal thoughts and behaviors Advise families and caregivers of the need for close observation and communication with the prescriber CYP1A2 inhibitors or thioridazine should not be coadministered Use caution in severe renal impairment, ESRD Heavy alcohol use Suicidality; monitor for clinical worsening and suicide risk, especially in children, adolescents and young adults (18-24 years) during early phases of treatment and alterations in dosage Serotonin syndrome or neuroleptic malignant syndrome-like reactions may occur; discontinue and initiate supportive therapy; closely monitor patients concomitantly receiving triptans, antipsychotics and serotonin precursors Neonates exposed to serotonin-noreponephrine reuptake inhibitors (SNRIs) or selective serotonin reuptake inhibitors (SSRIs) late in 3rd trimester of pregnancy have developed complications necessitating prolonged hospitalization, respiratory support, and tube feeding Screen patients for bipolar disorder; risk of mixed/manic episodes is increased in patients treated with antidepressants May cause activation of mania or hypomania Increased risk of hepatotoxicity, sometimes fatal; monitor for abdominal pain, hepatomegaly, elevations in hepatic transaminases exceeding 20 times upper limit of normal; jaundice; cholestatic jaundice with minimal elevations of hepatic transaminases have also been reported; use not recommended in patients with substantial alcohol use or chronic liver disease SSRIs and SNRIs may impair platelet aggregation and increase the risk of bleeding events, ranging from ecchymoses, hematomas, epistaxis, petechiae, and GI hemorrhage to life-threatening hemorrhage; concomitant use of aspirin, NSAIDs, warfarin, other anticoagulants, or other drugs known to affect platelet function may add to this risk Severe skin reactions (eg, erythema multiforme and Stevens-Johnson syndrome); discontinue at first appearance of blisters, peeling rash, mucosal erosions, or any other sign of hypersensitivity if no other etiology can be identified Orthostatic hypotension and syncope, especially during week 1 of therapy; monitor patients taking drugs that increase risk of orthostatic hypotension; consider dose reduction or discontinue therapy in patients who experience symptomatic orthostatic hypotension, falls and/or syncope Hyponatremia due to syndrome of inappropriate antidiuretic hormone (SIADH); cases of serum sodium Exact mechanism of action unknown; inhibits reuptake of serotonin and norepinephrine; weakly inhibits reuptake of dopamine; has no MAOI activity; has no significant activity for histaminergic H1 receptor or alpha2-adrenergic receptor The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

    Duloxetina

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  7. Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor antidepressant SSNRI. Duloxetine affects chemicals in the brain that may be unbalanced in people with depression. Duloxetine is used to treat major depressive disorder in adults. Duloxetine is also used to treat general.

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    Duloxetina VIR contiene el principio activo duloxetina. Duloxetina VIR aumenta los niveles de serotonina y noradrenalina en el sistema nervioso. Duloxetina. La duloxetina es un antidepresivo en un grupo de medicamentos llamados inhibidores selectivos de la recaptación de serotonina y noradrenalina IRSN, afecta a los químicos en su cerebro que pueden salir de balance y causar depresión. Pregunta de la revisión. ¿La duloxetina es efectiva para tratar el dolor generado por los nervios dañados a causa de enfermedades, o el dolor.

     
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