Metformin is a prescription drug used to treat type 2 diabetes. It belongs to a class of medications called biguanides. People with type 2 diabetes have blood sugar (glucose) levels that rise higher than normal. Instead, it helps lower your blood sugar levels to a safe range. This may make you wonder what side effects it can cause. Metformin can cause mild and serious side effects, which are the same in men and women. Here’s what you need to know about these side effects and when you should call your doctor. Find out: Can metformin be used to treat type 1 diabetes? These can occur when you first start taking metformin, but usually go away over time. Tell your doctor if any of these symptoms are severe or cause a problem for you. The UK Prospective Diabetes Study, a large clinical trial performed in 1980-90s, provided evidence that metformin reduced the rate of adverse cardiovascular outcomes in overweight patients with type 2 diabetes relative to other antihyperglycemic agents. Treatment guidelines for major professional associations including the European Association for the Study of Diabetes, the European Society for Cardiology and the American Diabetes Association, now describe evidence for the cardiovascular benefits of metformin as equivocal. In 2017, the American College of Physicians's guidelines were updated to recognize metformin as the first-line treatment for type-2 diabetes. For example, a 2014 review found tentative evidence that people treated with sulfonylureas had a higher risk of severe low blood sugar events (RR 5.64), though their risk of non-fatal cardiovascular events was lower than the risk of those treated with metformin (RR 0.67). There was not enough data available at that time to determine the relative risk of death or of death from heart disease. study known as the Diabetes Prevention Program, participants were divided into groups and given either placebo, metformin, or lifestyle intervention and followed for an average of three years. Metformin treatment of people at a prediabetes stage of risk for type 2 diabetes may decrease their chances of developing the disease, although intensive physical exercise and dieting work significantly better for this purpose. The intensive program of lifestyle modifications included a 16-lesson training on dieting and exercise followed by monthly individualized sessions with the goals of decreasing weight by 7% and engaging in physical activity for at least 150 minutes per week. The incidence of diabetes was 58% lower in the lifestyle group and 31% lower in individuals given metformin. Among younger people with a higher body mass index, lifestyle modification was no more effective than metformin, and for older individuals with a lower body mass index, metformin was no better than placebo in preventing diabetes. Sildenafil stability Cialis chemist warehouse Diabetes Res Clin Pract. 2015 May;1082336-41. doi 10.1016/j.diabres.20. Epub 2015 Feb 23. Metformin utilisation in Australian community and. Metformin is a prescription drug used to treat type 2 diabetes. It belongs to a class of medications called biguanides. People with type 2 diabetes have blood sugar glucose levels that rise. 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Metformin is the first drug of choice in the treatment of high blood glucose levels in adults and children over 10 years of age with type 2 diabetes. It is also used for people with gestational diabetes and polycystic ovary syndrome. It is especially useful for people who are overweight or obese, when diet and exercise are not enough to lower high blood glucose levels. In adults, Metformin can be used alone, or in combination with other oral diabetes medications, or in combination with insulin. It works on both fasting blood glucose levels as well as after meals, by lowering the amount of glucose made by the liver, which in turn makes the body’s cells more sensitive to the action of insulin, and delays the uptake of glucose by the gut. All this without increasing risk of hypoglycaemia (low blood glucose levels). It may also lower cholesterol and triglycerides, and promote a small amount of weight loss. 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