Tamoxifen and stroke

Discussion in 'Prescription Price Comparison' started by Dzmitry, 02-Sep-2019.

  1. magNETic Well-Known Member

    Tamoxifen and stroke


    Tamoxifen blocks the actions of estrogen, a female hormone. Certain types of breast cancer require estrogen to grow. Tamoxifen is used to treat some types of breast cancer in men and women. Tamoxifen is also used to lower a woman's chance of developing breast cancer if she has a high risk (such as a family history of breast cancer). Tamoxifen may also be used for purposes not listed in this medication guide. Hormonal contraception (such as birth control pills, injections, implants, skin patches, and vaginal rings) may not be effective enough to prevent pregnancy while taking tamoxifen. Ask your doctor about using non hormonal birth control (condom, diaphragm with spermicide, or intrauterine device/IUD). Patients who take a commonly prescribed breast cancer drug, Tamoxifen (learn more about Tamoxifen here) are at an increased risk of developing blood clots. Researchers have discovered that this risk is much greater (500% higher) in some patients with a specific genetic mutation, called “Factor 5 Leiden” or FVL mutation. In my opinion, any patient who is on Tamoxifen and who is already at a high risk of blood clots (see the list of risk factors, below) should be offered this test. If you carry this mutation, you may be offered alternative medications (i.e. aromatase inhibitors) with no increased risk of blood clots.

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    Sep 6, 2017. For women at higher risk of breast cancer, drugs such as tamoxifen and. increase your risk of heart attack or stroke, although this is not clear. Find information about tamoxifen, a medicine to treat breast cancer, from. women with a history of blood clots or stroke or those who are taking anticoagulants. Tamoxifen, an antiestrogen agent that has been used for 20 years to treat breast cancer, does not increase a woman's risk for stroke. Earlier.

    The use of aromatase inhibitors, hormone-therapy drugs used to treat patients with breast cancer, was not associated with an increased risk of fatal cardiovascular events, including heart attacks or stroke, compared with tamoxifen, another commonly prescribed anti-cancer drug that works on hormones and which has been associated with a serious risk of stroke, report investigators. In a new study from Kaiser Permanente, researchers found the use of aromatase inhibitors, hormone-therapy drugs used to treat patients with breast cancer, was not associated with an increased risk of fatal cardiovascular events, including heart attacks or stroke, compared with tamoxifen, another commonly prescribed anti-cancer drug that works on hormones and which has been associated with a serious risk of stroke. , found that those who only used aromatase inhibitors or used the drugs after tamoxifen treatment had a 26 to 29 percent higher risk of less serious cardiovascular events, such as abnormal heart beat and pericarditis (a swelling and irritation of the thin membrane surrounding the heart), compared with those who only used tamoxifen. Cardiovascular disease is a leading cause of death in older breast cancer survivors. Although aromatase inhibitors are considered superior in reducing risk of cancer recurrence compared to tamoxifen in postmenopausal women with hormone receptor positive breast cancer, previous studies have provided inconclusive or mixed results on the potential cardiovascular risk associated with aromatase inhibitors. "Our study is a comprehensive assessment of the impact aromatase inhibitors have on cardiovascular risk and provides reassurance that the hormone therapy to reduce breast cancer recurrence does not increase risk of the most fatal cardiovascular events," noted Reina Haque, Ph D, MPH, research scientist, Kaiser Permanente Southern California Department of Research & Evaluation. "A particular strength of our study is that we accounted for women's other potential cardiovascular risk factors as well as medication used to treat high blood pressure and high cholesterol." Estrogen and progesterone are hormones produced by women that can promote the growth of some breast cancers. Tamoxifen (Nolvadex®) is a medication in pill form that has been used for more than 25 years to treat breast cancer in women and men. Tamoxifen is one of the most common endocrine therapy drugs. It has been shown to decrease the chance of recurrence in some early-stage breast cancers and to prevent the development of cancer in the opposite breast. Tamoxifen can also slow or stop the growth of cancer cells present in the body. There are an estimated 29 million women at increased risk for breast cancer in this country, and tamoxifen may offer another alternative to watchful waiting or prophylactic (preventative) mastectomy. Tamoxifen is classified as a selective estrogen receptor modulator (SERM) and works as an anti-estrogen: While the hormone estrogen promotes the growth of breast cancer cells, tamoxifen works by blocking estrogen from attaching to estrogen receptors on these cells. By blocking the estrogen receptors, it is believed that the growth of the breast cancer cells will be halted.

    Tamoxifen and stroke

    Time dependent effects of adjuvant tamoxifen therapy on. - Nature, Tamoxifen & Breast Cancer Cleveland Clinic

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  3. Oct 17, 2017. Bushnell, C. D. and Goldstein, L. B. 2004. Risk of ischemic stroke with tamoxifen treatment for breast cancer a meta-analysis. Neurology 63.

    • Frontiers Tamoxifen Use Correlates with Increased Risk of the First..
    • Are Tamoxifen and Stroke Linked? - Pharmacy Times.
    • Tamoxifen MedlinePlus Drug Information.

    Whether tamoxifen increases the risk of a stroke has been unclear; a couple of studies have found a reduced risk and several found an increased risk. stroke risk posed by tamoxifen. To determine the stroke risk posed by tamoxifen, Duke University researchers pooled findings from nine clinical trials involving about 40,000 breast cancer patients. The preponderance of clinical evidence suggests that tamoxifen increases stroke risk and has no effect or modestly reduces CHD risk. Aromatase inhibitors. To assess the overall risk of stroke, specifically ischemic stroke, associated with tamoxifen use by performing a meta-analysis of data reported in breast cancer.

     
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